Background: In sickle cell disease (SCD). reduced bioavailability of endothelial NO and cGMP results in reduced expression of phosphodiesterase type 5 (PDE5). thus impairing the penile erection control mechanism and resulting in prolonged penile erection (priapism). In SCD. https://www.roneverhart.com/Cortech-Sonic-Flo-Plus-Waterproof-Men-s-Street-Gloves/